projectS

PLANNED AND ONGOING PROJECTS

Cape Global is currently focusing on strengthening the public health responses in the United States communities.

Healthcare Services and Project Topics for Underserved Communities in the United States

Assessing healthcare needs among immigrant populations.
Developing community health clinics tailored to immigrant communities.
Evaluating the effectiveness of language interpretation services in improving healthcare access.
Analyzing barriers to HIV testing and treatment adherence.
Assessing healthcare workforce shortages in rural areas.

Public Health Responses to COVID-19 Pandemic in Selected United States Communities

The organization is at the forefront of providing the needed evidences for preventive and control measures. We are currently working on the following studies that will help with COVID-19 control measures:

COVID-19 vaccine hesitancy and the role of social media in United States.
Improving COVID-19 vaccine uptake within the American communities: Analyzing social media platforms for solutions.
Developing an overview of treatment guidelines for COVID-19.

PAST PROJECTS INVOLVING TEAM MEMBERS

COVID-19

Cochrane corner: universal screening for SARS-CoV-2 infection
Implications of COVID-19 in high burden countries for HIV/TB: A systematic review of evidence. https://doi.org/10.1186/s12879-020-05450-4
Classification Schemes of COVID-19 High-Risk Areas and Resulting Policies (Under review).
Projected early spread of COVID-19 in Africa through 1 June 2020. Eurosurveillance. 2020 May 7;25(18):2000543. https://doi.org/10.2807/1560-7917.ES.2020.25.18.2000543
South African National Department of Health. Brief Report of Rapid Review. Colchicine for COVID‐19: Evidence review of the clinical benefit and harm. August 2020. https://www.knowledgehub.org.za/system/files/elibdownloads/2020-08/Rapid%20review%20of%20Colchicine%20for%20COVID-19_6August2020.pdf

HIV

Subnational mapping of HIV incidence and mortality among individuals aged 15-49 years in sub-Saharan Africa, 2000-18: a modelling study. https://doi.org/10.1016/S2352-3018(21)00051-5
Effect of community-based interventions targeting female sex workers along the HIV care cascade in sub-Saharan Africa: a systematic review and meta-analysis. https://doi.org/10.1186/s13643-021-01688-4
Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems. https://doi.org/10.1186/s12916-020-01876-4
Epidemiology of multimorbidity among people living with HIV in sub-Saharan Africa: a systematic review protocol. https://doi.org/10.1186/s12879-020-05450-4
Effect of female sex work-targeted community-based interventions along the HIV treatment cascade in sub-Saharan Africa: a systematic review protocol. https://doi.org/10.1136/bmjopen-2020-039495
Shifting tasks from pharmacy to non-pharmacy personnel for providing antiretroviral therapy to people living with HIV: a systematic review and meta-analysis. https://doi.org/10.1136/bmjopen-2016-015072
Eliminating mother-to-child transmission of the human immunodeficiency virus in sub-Saharan Africa: The journey so far and what remains to be done. https://doi.org/10.1016/j.jiph.2015.06.010
Community-Based Interventions to Improve and Sustain Antiretroviral Therapy Adherence, Retention in HIV Care and Clinical Outcomes in Middle- and Low-Income Countries: https://doi.org/10.1007/s11904-016-0325-9
Efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV infected children and adolescents: a systematic review and meta-analysis. https://doi.org/10.1186/s12879-015-1183-6
Antiretroviral Treatment and Resistance Patterns in HIV-Infected Children. https://doi.org/10.1007/s11908-015-0502-9
Antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children and adolescents: a systematic review protocol. https://doi.org/10.1186/s12879-015-1183-6
Distribution and Determinants of HIV Prevalence in South Africa. https://doi.org/10.1016/j.annepidem.2020.08.061
The effectiveness of a quality improvement collaborative to accelerate elimination of mother to child transmission (eMTCT): key outcomes and determinants from a demonstration phase collaborative implemented in South Africa, 2012-2015. https://onlinelibrary.wiley.com/doi/epdf/10.7448/IAS.19.6.21264
Coverage of antiretroviral and cotrimoxazole prophylactic therapies among HIV-positive tuberculosis patients in Africa region. http://barcelona.worldlunghealth.org/programme/body/Abstract_Book_2014-Web.pdf
Trends in paediatric antiretroviral and cotrimoxazole prophylaxis coverage among the priority countries. http://regist2.virology-education.com/abstractbook/2014_6.pdf
Assessing the global coverage of antiretroviral and cotrimoxazole prophylactic therapies among HIV/TB co-infected patients. https://onlinelibrary.wiley.com/doi/10.1111/tmi.12575
Role and Trend of Maternal Antiretroviral Therapy in Preventing Mother-to-Child-transmission of HIV in Sub-Saharan Africa. https://doi.org/10.1089/aid.2014.5595.abstract
Awareness, Knowledge of HIV and Utilisation of HIV Preventive Services among Young People in Nigeria. https://doi.org/10.1089/aid.2014.5258.abstract
Prevention of Mother-to-Child-transmission: Antiretroviral Coverage and Access to Virological Testing during Breastfeeding. https://doi.org/10.1089/aid.2014.5596.abstract

VACCINOLOGY

Missed opportunities for vaccination in Africa. https://doi.org/10.1016/j.coi.2021.05.002
The Impact of Rubella Vaccine Introduction on Rubella Infection and Congenital Rubella Syndrome: A Systematic Review of Mathematical Modelling Studies. https://doi.org/10.3390/vaccines9020084
Immunogenicity and safety of fractional dose yellow fever vaccination: A systematic review and meta-analysis. https://doi.org/10.1016/j.vaccine.2019.12.018
Vaccination among HIV–infected, HIV-exposed uninfected and HIV-uninfected children: A systematic review and meta-analysis of evidence related to vaccine efficacy and effectiveness. https://doi.org/10.1080/21645515.2019.1599677
The burden of vaccine-preventable diseases among HIV-infected and HIV-exposed children in sub-Saharan Africa: a systematic review and meta-analysis. https://doi.org/10.1080/21645515.2019.1599676
A multilevel analysis of the determinants of missed opportunities for vaccination among children attending primary healthcare facilities in Kano, Nigeria: Findings from the pre-implementation phase of a collaborative quality improvement programme. https://doi.org/10.1371/journal.pone.0218572
Non-specific effects of childhood vaccines on acute childhood morbidity among HIV-exposed children in sub-Saharan Africa: a multilevel analysis. https://doi.org/10.1080/21645515.2018.1516490
Morbidity benefit conferred by childhood immunisation in relation to maternal HIV status: a meta-analysis of demographic and health surveys. https://doi.org/10.1080/21645515.2018.1515453
Non-uptake of childhood vaccination among the children of HIV-infected mothers in sub-Saharan Africa: A multilevel analysis. https://doi.org/10.1080/21645515.2018.1502524
Effect of maternal HIV status on vaccination coverage among sub-Saharan African children: A socio-ecological analysis. https://doi.org/10.1080/21645515.2018.1467204
Children who have received no routine polio vaccines in Nigeria: Who are they and where do they live? https://doi.org/10.1080/21645515.2017.1336590
Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1. https://doi.org/10.1016/S0140-6736(21)00984-3
The Epidemiological Trend of Poliovirus in Nigeria (2009-2013). https://doi.org/10.1093/ije/dyv097.249

TUBERCULOSIS

BCG vaccination in sub-Saharan Africa: coverage, geographical variations and the hotspots. http://www.abstractserver.com/union2016/abstractbook/UNION_Abstract_Book_2016-Web.pdf

MALARIA

Usage and impact of insecticide-treated nets in Africa.

GLOBAL HEALTH

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019. https://doi.org/10.1016/S0140-6736(21)01207-1
Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning. https://doi.org/10.1371/journal.pntd.0008824
Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. https://doi.org/10.1016/S0140-6736(20)30752-2
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. https://doi.org/10.1016/S0140-6736(20)30977-6
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. https://doi.org/10.1016/S0140-6736(20)30925-9
Five insights from the Global Burden of Disease Study 2019. https://doi.org/10.1016/S0140-6736(20)31404-5
The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis. https://doi.org/10.1016/S2214-109X(20)30286-2
Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17. https://doi.org/10.1016/S2214-109X(20)30278-3
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. https://doi.org/10.1016/S0140-6736(20)30750-9
Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017. https://doi.org/10.1016/S0140-6736(20)30114-8
Mapping local patterns of childhood overweight and wasting in low-and middle-income countries between 2000 and 2017. https://doi.org/10.1038/s41591-020-0807-6
Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000–17. https://doi.org/10.1016/S2214-109X(20)30230-8
Does economic growth reduce childhood stunting? A multicountry analysis of 89 Demographic and Health Surveys in sub-Saharan Africa. http://dx.doi.org/10.1136/bmjgh-2019-002042
Global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. https://doi.org/10.1016/S2352-3018(19)30196-1
Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. https://doi.org/10.1016/S0140-6736(18)31310-2
Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016. https://doi.org/10.1016/S0140-6736(18)30994-2
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. https://doi.org/10.1016/S0140-6736(18)32279-7
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. https://doi.org/10.1016/S0140-6736(18)32203-7
Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. https://doi.org/10.1016/S0140-6736(18)32281-5
Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017. https://doi.org/10.1016/S0140-6736(18)31891-9
Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017. https://doi.org/10.1016/S0140-6736(18)32278-5
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. https://doi.org/10.1016/S0140-6736(18)32335-3
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. https://doi.org/10.1016/S0140-6736(18)32225-6
Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. https://doi.org/10.1016/S0140-6736(17)32130-X
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. https://doi.org/10.1016/S0140-6736(17)32154-2
Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. https://doi.org/10.1016/S0140-6736(17)32336-X
Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016. https://doi.org/10.1016/S0140-6736(17)31833-0
Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016. https://doi.org/10.1016/S0140-6736(17)32152-9
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016. https://doi.org/10.1016/S0140-6736(17)32366-8

MATERNAL AND CHILD HEALTH

Engaging community health workers in maternal and infant death identification in Khayelitsha, South Africa: a pilot study. https://doi.org/10.1186/s12884-020-03419-4

CANCER STUDIES

Geographical Distribution of Three AIDS-related Cancers Among Children In The Six WHO Regions: p-198. Pediatric Blood & Cancer. 2015 Nov 1;62:S289.

Regional epidemiological pattern of aids-related cancers in children. http://sti.bmj.com/content/91/Suppl_2/A213.2

Epidemiology of Childhood Cancer in Western African Region: Assessing Gender Differences. Pediatric Blood & Cancer. 2014 Dec 1 (vol. 61, pp. s288-s288).

OTHERS

African based researchers’ output on models for the transmission dynamics of infectious diseases and public health interventions: A scoping review. https://doi.org/10.1371/journal.pone.0250086
Predictors of post-operative outcomes in patients with peripheral arterial disease and critical limb ischaemia: a systematic review and meta-analysis. http://dx.doi.org/10.4314/gmj.v55i1.10
Mapping oral cancer research in South Africa. http://dx.doi.org/10.17159/2519-0105/2018/v73no6a1
Isoniazid for preventing tuberculosis in HIV‐infected children. https://doi.org/10.1002/14651858.CD006418.pub3
Building capacity in Clinical Epidemiology in Africa. https://doi.org/10.1186/s12909-017-0885-4
Smoke free legislations in sub–Saharan African countries: Progress update. http://barcelona.worldlunghealth.org/programme/body/Abstract_Book_2014-Web.pdf